Bridging Continents, Biology & Physics
QBS Journey to the Quantum Sensing Labs of Groningen
Science is rooted in conversations. The cooperation of different people may culminate in scientific results of the utmost importance. — Werner Heisenberg
It’s easy to think of research as a solitary pursuit in a quiet lab. But as Heisenberg suggested, true breakthroughs happen when people talk. That was the driving force behind our trip to Groningen.
This past week, our team traveled from Bengaluru and the US to the historic city of Groningen, Netherlands. Our goal was simple: to collaborate and strengthen our partnership with QTSense, the creators of the Quantum Nuova platform. We arrived expecting a technical deep dive. We left with something far more profound: a stronger global alliance built on cutting-edge physics, rigorous biology, and a cultural warmth that made the Dutch winter feel remarkably inviting.
The Team
To truly evaluate the Quantum Nuova platform, we needed a convergence of disciplines. By bringing these domain experts together on the ground in Groningen, we were able to assess the technology holistically—bridging the gap between theoretical quantum sensing and practical biological application in real-time.
Day 1: The Theory of Everything
Our first day at the QTSense office was a deep dive into architecture. Before operating the machine, we needed to deconstruct the "why" behind the signal.
The QTSense Scientific Team took the lead on the biology side, delivering a comprehensive introduction to Reactive Oxygen Species (ROS) and free radical generation. They walked us through their application data, detailing how they track mitochondrial stress responses with exceptional precision. It was incredibly validating to see their data mirroring the biological pathways we focus on at QBS.
Simultaneously, the QTSense Technology Team deconstructed the physics. They broke down the principles of Quantum Sensing and how the platform detects the magnetic noise generated by these free radicals to deliver a clear signal. Between the two teams, we bridged the gap between quantum physics and cellular biology.
Day 2 & 3: Getting our Hands Dirty
For the next two days, we moved our base of operations to the University Medical Center Groningen (UMCG) to work in Professor Romana Schirhagl’s lab.
This wasn't a polished demo; it was an apprenticeship. Our engineering and biology leads took the lead on the hands-on work. Under the guidance of the QT Sense Scientific Team, they learned the "tips and tricks" that you just can't get from a manual.
The focus was on reproducibility and precision in a Biosafety Level (BSL) environment.
- Target Acquisition: We learned the nuances of navigating to specific intracellular nanodiamonds within live cells.
- Measurement: The team performed precise measurements to establish baseline metabolic states, learning to distinguish between healthy baselines and stressed states.
- The "Insult" Test: We introduced stressors to observe the sensor's response in real-time.
- Sample Prep: We dove into the nuances of preparing cells with nanodiamonds, a critical step to ensuring valid data in a Biosafety Level (BSL) lab.
By the end of the sessions, the team felt confident in operating the Quantum Nuova equipment.
Day 4: Defining the Future
While the biology team was deep in the weeds of experimentation, our CTO sat down with the QTSense Technology team for a critical discussion on the future of the platform.
The conversation emphasized that to truly understand oxidative stress, we need to go beyond static curves and capture the dynamic nature of ROS formation in real-time. The QTSense team was incredibly receptive and open to further discussions on opening up the system's data streams so we can analyze these dynamic signatures with our own algorithms.
We also discussed the roadmap for scaling the technology. We aligned on the need to transition the hardware from a research-focused instrument to a system capable of handling clinical workflows. By integrating our specific requirements for process integration, we are helping shape a next-generation device that is aligned with clinical market needs.
Why we Chose Quantum Nuova
At Quantum Biosciences, our requirements are rigorous. We didn't just need a sensor; we needed a window into cellular metabolism. We selected the Quantum Nuova platform because it offers a unique capability to measure oxidative stress non-invasively and in real-time.
Unlike standard fluorescence methods that often suffer from bleaching or lack sensitivity at the nanoscale, the Quantum Nuova platform leverages quantum sensing to provide stable, quantifiable data. This precision is critical for our work in validating biomarkers for clinical use. It is currently the only platform that bridges the gap between quantum physics theoretical potential and biological reality.
Strategic Alignment: The Global Triangle
Simultaneously, the leadership teams from both companies engaged in strategic mapping. We solidified what we call a "Global Triangle"—a collaborative model where the lines between our teams are intentionally fluid.
While QTSense anchors the foundational quantum physics and sensor technology, QBS is stepping in to drive the system-level innovation required to make this technology clinical-grade. We are actively exploring advanced architectures and system integration strategies—moving beyond the current form factor to design high-throughput, field-deployable units. By combining QTSense's core engine with our vision for scalable hardware, we are building a device that is ready for the real world, not just the research lab.
Academic Validation: Bridging the Gap
A true highlight was grabbing lunch with Professor Romana Schirhagl and her team from QTSense at De Kostery, a historic spot right by the Martinikerk church.
Over bowls of traditional Groningen Mustard Soup (highly recommended!), the conversation moved from pleasantries to a candid assessment of the quantum sensing landscape. Romana highlighted a critical gap in the industry: while we are seeing massive advancements in the technology, they almost exclusively exist in research settings. There is a distinct lack of reliable, standardized product offerings that can survive outside a university lab.
This is where our conversation found common ground. She validated that the current QTSense platform is a powerful engine for biological research—one that her team uses extensively. When we discussed QBS’s plans, she found our specific application focus intriguing.
Even more encouraging was her reaction to working together. When we brought up the possibility of collaboration, her response was immediate and enthusiastic. She made it clear that despite her packed schedule, she would absolutely make time to partner with us on future technology and clinical initiatives.
On a personal level, Romana is an inspiration. Seeing how she seamlessly balances a high-profile academic career, her entrepreneurial role with QTSense, and a busy family life is incredible. It was a reminder that the best leaders don't just drive science; they manage to keep life in perspective, too.
The Human Element & The Dutch Experience
While the science was rigorous, the trip was defined by the warmth of our hosts. The local team went above and beyond to make us feel welcome. They didn't just host meetings; they ensured our stay was comfortable, we were well-fed, and made us feel like part of the local family rather than just visiting partners.
Outside the office, we quickly realized that Groningen has its own rhythm—one we had to learn the hard way.
The Commute: We found out quickly that Uber isn't the king of transport here. After shivering in the cold while drivers canceled on us, we switched to the local bus system. It became our trusted mode of transport - punctual, spotless, and far more reliable.
The Sugar Rush: The team took on the infamous "Tompouce Challenge," introduced to us by the local team—trying to eat a cream-filled pastry without it exploding all over us. (Spoiler: The pastry won). We also discovered that proper Dutch hot chocolate involves melting a solid block of chocolate into hot milk yourself.
The Symphony of Bikes: You are warned constantly to "watch out" for cyclists, but seeing it in person is different. It’s not just traffic; it’s a high-speed, silent flow. We stuck to walking, but watching an entire city move so efficiently on two wheels was a sight to behold.
Looking Forward
We returned from Groningen with more than just valid data points. We returned with a shared vision and a partner fully aligned with our strategy.